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CIT2020|Online Release Conference of MemoLefort® Left Atrial Appendage (LAA) Closure Occluder I A Great Success: Domestic Apparatus Offers Aid in ‘Domestication’ of LAA Closure

2020-08-07

On August 7, 2020, during the commensurate period of the fourth online session of the 18th China Conference of Interventional Cardiology (CIT2020), the online conference of MemoLefort® Left Atrial Appendage (LAA) Closure Occluder I was successfully held, and many domestic forerunner experts in related fields were invited to attend it and shared and discussed clinical trial results of MemoLefort®Left Atrial Appendage (LAA) Closure Occluder I and their clinical application experience of LAA occlusion technology.

 

This online press conference invited Professor Cao Kejiang from Jiangsu Provincial People's Hospital, Professor Fang Weiyi, Dean of Hefei High-tech Cardiovascular Hospital under Lepu Medical, Professor Huang He from Wuhan University People's Hospital, and Professor Zhang Shu from Fuwai Hospital, Chinese Academy of Medical Sciences as chairmen, and invited Professor Chen Wei from the Tenth People's Hospital of Tongji University, Professor Niu Guodong from Fuwai Hospital of Chinese Academy of Medical Sciences, and Professor Zhou Daxin from Zhongshan Hospital of Fudan University to give wonderful keynote speeches. (In sequence of pinyin of surname)

 

Address of the conference

 

 

 As leading unit on clinical trial of MemoLefort LAA occluder, I am delighted to witness successful market launching of our domestic LAA occluder with a plug design. I would hereby send my congratulations to Lepu Medical and SHSMA.

 

China is a giant country in atrial fibrillation, but Chinese patients stricken with atrial fibrillation suffer poor compliance with medications, as oral anticoagulants in patients with non-valvular atrial fibrillation is a measly 11%. LAA occlusion has been applied in China for a space of 6 years. After years of development, its safety and effectiveness have been confirmed by a growing number clinical studies, and development of surgical methods and equipment has gradually taken on the road featuring Chinese characteristics, which can’t do without joint efforts by clinical works and medical apparatus manufacturers alike. We also hope that MemoLefort can become representative of domestic LAA occluders and thus contribute to treatment of more Chinese patients with atrial fibrillation problem and to development of cardiovascular diagnosis and treatment technology in China.

 

 

Atrial fibrillation is the most common arrhythmia in clinical practice. Its biggest menace lies on its proneness to cause thrombus in the atria that then fall off and enter the brain and then embolize the cerebrovascular and spawn stroke. For patients with atrial fibrillation problem who can’t receive anticoagulant treatment, LAA closure therapy is a major clinical measure to prevent stroke. Launching of a growing number domestic LAA closure occluders bears testament to that the current LAA closure in China is taking the lead worldwide.The online conference today is of great significance. Launching of domestic Memolefort® LAA Closure Occluder I is gigantic in value. I wish MemoLefort® LAA Closure Occluder I in China will grab sound effects in its domestic clinical application.

 

 

A tally of over 10 million patients are stricken with atrial fibrillation in China. LAA closure helps effectively prevent atrial fibrillation stroke, as is confirmed by massive clinical research data at home and abroad. That advanced technology of LAA closure can be applicable early in China can’t do without efforts and support of all parties.

It goes that 'acute weapons are needed to be successful’. Development of LAA closure in China calls for assistance from more excellent domestic devices. Marketing launching of MemoLefort® LAA Closure Occluder I, a domestic LAA occluder helps facilitate our work and boost our national pride and confidence.

We will strictly supervise symptoms in clinical application of LAA occluder and perform well in follow-up visit work. I believe that with support of top-notched domestic experts in various fields together with joint efforts of all clinicians, clinical application of LAA closure in China can be greeted with better and more completed development.

Wonderful lectures      

 

      

 

Features and atrial fibrillation stroke

Professor Huang He from the People's Hospital of Wuhan University mentioned in his lecture that LAA is a common site of thrombosis in patients suffering from atrial fibrillation. Changes in structure and function of LAA such as increased volume and gateway, decreased flow rate, shortened emptying and filling time and so on form pathophysiological basis of thrombosis. Shape of LAA is correlated with formation of thrombus, which may become a new indicator of stroke prediction in patients with atrial fibrillation. Dean Fang Weiyi also stated in his comments that patients with atrial fibrillation who are prone to thrombosis such as non-chicken-wing atrial appendages notably cauliflower atrial appendages and CHA2DS2-VASc scoring≥2 should receive LAA closure operation as soon as possible to prevent thrombosis, which will be conducive to reducing incidence of related strokes.

 

 

Clinical trials and application prospects of MemoLefort®LAA Closure Occluder I

On behalf of Professor Zhang Shu's team, Professor Niu Guodong from Fuwai Hospital of Chinese Academy of Medical Sciences shared a report on clinical trial and application prospects of MemoLefort® LAA Closure Occluder I. As team leader of  clinical trial, Professor Niu Guodong highly spoke of excellent results of the MemoLefort LAA Closure Occluder I in clinical trial. He also mentioned that due to  further acceleration of China's aging problem, the number of patients with atrial fibrillation in China will continue to rise in days to come and proportion of strokes will also be on ascendance. So development prospects of LAA occluder in China are  broad. President Fang Youyi also affirmed safety and effectiveness of MemoLefort LAA Occluder in his comments, and believed that emergence of this product would bring bliss to Chinese patients with atrial fibrillation.

 

 

Key points and operation skills of transseptal puncture

Professor Zhou Daxin from Zhongshan Hospital affiliated to Fudan University shared relevant experience on key points and techniques of transseptal puncture. He also mentioned that in actual use of MemoLefort LAA closure occluder I, clinical operation was convenient, sheath can be well coaxial with LAA during implants and occluder has good compliance after implantation. In clinical trials, occlusion was complete with no residual shunt. In his comments, Professor Fang Weiyi likened transatrial septal puncture to a key for ‘precise target’ in LAA closure surgery. He also aspired that Professor Zhou Daxin could share more relevant experience thanks to its  instructive significance for learning of this new technology among clinicians.

 

 

Experience Sharing of Single Center of MemoLefort®LAA Closure Occluder I

On behalf of Professor Xu Yawei's team in the tenth People's Hospital of Tongji University, center with most clinical trials of MemoLefort® LAA Closure Occluder I , Professor Chen Wei elaborated single-center application experience of MemoLefort LAA Occluder I. Professor Chen Wei mentioned that MemoLefort LAA Closure Occluder I could match similar products in the success rate of occlusion, stroke and related complications, and featured high safety and effectiveness. Professor Fang Youyi also gave his thumbs-up in his comments to MemoLefort® LAA Closure Occluder I is a reliable domestic occluder.

 

Good performance with a promising future

Stroke prevention is a major task in comprehensive management of atrial fibrillation. As an emerging device-based antithrombotic therapy, LAA occlusion is going through vigorous development after entering China, but standardization of its diagnosis and treatment process and large-scale promotion and application still calls for steady advancement in exploration and improvement. As a medical device manufacturer in related fields, SHSMA will actively cooperate with clinicians to combine mature technical concepts and high-quality products together to jointly promote healthy development of atrial fibrillation treatment and LAA closure in China so as to provide patients with more benefits.

 



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